(1774 - August 19, 1821) was a French painter, who specialized in portraits. She was born Marie-Denise Lemoine in Paris. She came from an artistic family, and her sisters Marie-Victoire Lemoine and Marie-Élisabeth Gabiou were also accomplished artists. In 1794, Marie-Denise married an architecture student, Michel-Jean-Maximilien Villers.
Villers was a student of the French painter Anne-Louis Girodet de Roussy-Trioson. She was first exhibited at the Paris Salon of the Year VII (1799). Villers' most famous painting, Young Woman Drawing, china oil painting Marie-Denise Villers Une etude de femme d'apres nature dit aussi Portrait de Madame Soustras